Abcam, ab154826, Anti-RAB39B antibody [EPR9651]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RAB39B antibody. Suitable for ICC/IF, WB, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9651,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RAB39B also known as Ras-related protein Rab-39B is a member of the Rab family of small GTPases which has a molecular mass of approximately 26 kDa. RAB39B is expressed in several tissues but it shows higher expression levels in the brain. Mechanically RAB39B is involved in the regulation of intracellular vesicle trafficking specifically linked to endosome dynamics. This protein functions by switching between active GTP-bound and inactive GDP-bound states influencing membrane trafficking along actin and tubulin networks.
Biological function summary
RAB39B plays a role in synapse function and maintenance. This protein associates with cellular membranes and is involved in the trafficking of AMPA receptors to the neuronal surface which impacts synaptic plasticity and neurotransmission. Although not typically described as part of a large complex RAB39B works in close association with other synaptic proteins to ensure proper synaptic function. Its function in neurons highlights the importance of precise vesicular trafficking in neurotransmitter release and synaptic strength.
Pathways
RAB39B is integral to the endocytic trafficking and recycling pathways. It collaborates with key proteins like Rab7 and Rab5 in these cellular processes ensuring the proper sorting and recycling of synaptic vesicles. This precise control contributes to cellular homeostasis and efficient signal transmission at synapses which is critical for neuronal communication and overall brain function.
RAB39B is linked to neurodevelopmental disorders and has a significant connection to Parkinson's disease. Mutations in RAB39B can lead to intellectual disabilities and autism spectrum disorders. In the context of Parkinson's disease altered RAB39B function has been associated with the pathogenesis where it interacts with alpha-synuclein a protein significantly implicated in the disorder. These connections highlight the importance of RAB39B in maintaining neurological health and its potential as a therapeutic target.