Abcam, ab154846, Anti-GNAZ antibody [EPR8654]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GNAZ antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8654,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GNAZ also known as Guanine nucleotide-binding protein G(z) subunit alpha functions as a modulator or transducer in various transmembrane signaling systems. The protein plays an essential role in coupling cell surface receptors to intracellular signaling pathways. GNAZ weighs approximately 41.5 kDa and is widely expressed in human brain tissues and certain neuroendocrine tissues.
Biological function summary
GNAZ connects with receptor-mediated signal transduction aiding in neurotransmitter release and sensory perception. GNAZ functions as part of the heterotrimeric G-protein complex which includes G beta and G gamma subunits. This protein often regulates signal transduction cascades that influence cellular responses to external stimuli.
Pathways
GNAZ is closely linked to important signaling pathways such as the serotonergic signaling pathway and the phototransduction pathway. Within these pathways GNAZ interacts with kinases and ion channels influencing cellular responses and synaptic functions. GNAZ works alongside related proteins such as GNAI and GNAT contributing to the regulation of neurotransmitter systems.
GNAZ relates to neurological disorders and certain psychiatric conditions including schizophrenia and bipolar disorder. Changes in the activity or expression of GNAZ may impact neurotransmitter systems which are fundamental to these conditions. Through these disorders GNAZ connects with proteins like GNB and GNG pointing to its involvement in signal processing abnormalities that underlie these diseases.