Abcam, ab154854, Anti-TCEB2/Elongin-B antibody [EPR10441(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TCEB2/Elongin-B antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10441(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TCEB2 also known as Elongin-B is a protein that is part of the Elongin complex. It has an approximate molecular mass of 14 kDa. Elongin-B is widely expressed in various tissues including the heart liver and kidney. This protein works mechanically by increasing the transcription elongation efficiency of RNA polymerase II which is key for proper gene expression. Elongin-B functions within a cellular environment where it modulates transcriptional processes.
Biological function summary
Elongin-B participates as a component of the Elongin complex which also includes Elongin-C and Elongin-A. This complex enhances the rate of transcriptional elongation by alleviating the effects of transcriptional pausing or stalling. By facilitating the transcription of DNA to mRNA Elongin-B indirectly influences various cellular functions and growth processes. It acts by stabilizing other subunits of the complex contributing to the overall efficiency of gene expression systems.
Pathways
Elongin-B takes part in the ubiquitin-proteasome pathway a critical cellular system for protein degradation and turnover. It partners with others like Von Hippel-Lindau (VHL) protein within this pathway. Apart from protein degradation Elongin-B is also involved in the regulation of hypoxia-inducible factor (HIF) connecting it to pathways related to cellular response to oxygen levels. This interaction illustrates the protein's role in managing levels of various proteins related to stress responses in cells.
Elongin-B has implications in cancer and von Hippel-Lindau disease. Abnormal functioning or expression influences cellular mechanisms like uncontrolled cell growth seen in cancer proliferation. Elongin-B's interaction with VHL protein affects von Hippel-Lindau syndrome a condition that leads to tumor and cyst development in different parts of the body. The study of Elongin-B's role in these pathologies helps in understanding disease progression and identifying potential therapeutic targets.