Abcam, ab154861, Anti-GRAMD2 antibody [EPR10060]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GRAMD2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10060,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GRAMD2 also known as GRAM domain containing 2 is a protein with a molecular mass of approximately 67 kDa. It exists within various cellular compartments including the endoplasmic reticulum (ER) and the Golgi apparatus. Its expression is generally widespread but it is particularly noticeable in the brain and several other tissues. Mechanically GRAMD2 participates in membrane interactions and lipids binding which helps maintain structural organization within cells. The GRAM domain within GRAMD2 is significant for these interactions allowing the protein to bind to specific lipid membranes.
Biological function summary
The GRAM domain along with additional structural features of GRAMD2 plays a role in lipid-related cellular processes. GRAMD2 acts as a part of larger protein complexes that are responsible for regulating intracellular signaling and trafficking. Its interactions with lipid membranes are essential for maintaining cellular homeostasis particularly involving lipid metabolism. This coordination is essential for various cellular functions including the response to cellular stress and membrane repair mechanisms.
Pathways
GRAMD2 integrates into cellular signaling and lipid metabolism pathways. It is notably linked with the mTOR signaling pathway an important regulator of cell growth and homeostasis. GRAMD2 interacts with proteins like mTOR and Rheb which are involved in energy sensing and metabolic regulation. Another connected pathway is the phosphoinositide signaling pathway which further involves GRAMD2 in regulating lipid dynamics within the cell emphasizing its role in sustaining cellular balance.
GRAMD2 alterations connect to conditions like neurodegenerative diseases and specific forms of cancer. It shows associations with proteins such as Tau in Alzheimer's disease suggesting that changes in lipid binding and processing could affect tau pathology. Additionally dysregulation of GRAMD2 has been implicated in lipid metabolism disorders a factor contributing to metabolic syndromes. These connections highlight the importance of GRAMD2 in maintaining lipid balance influencing disease progression and highlighting its potential as a therapeutic target.