Abcam, ab154866, Anti-GNB3 antibody [EPR8862]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GNB3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8862,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GNB3 also known as Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 functions as an integral component of heterotrimeric G proteins. The protein has a mass of approximately 37 kDa. GNB3 is expressed in various tissues with significant expression in the brain and heart. It forms part of the G protein complex essential for transmitting signals from many hormones neurotransmitters and other signaling factors.
Biological function summary
GNB3 interacts with alpha and gamma subunits to mediate signal transduction from G protein-coupled receptors (GPCRs). It plays a role in sensory perception neurotransmission and regulation of ion channels and certain enzymes. GNB3 is part of the G protein complex which appears critical in maintaining cellular response and adaptation to external signals. The interaction with different G protein subunits enables diverse regulatory effects on cellular functions.
Pathways
GNB3 participates in the GPCR signaling pathway and the calcium signaling pathway. It interacts with G protein alpha subunits like GNAI1 and GNAS which are key players in these pathways. GPCR signaling affects numerous physiological processes involving aspects like cellular growth development and metabolic regulation. GNB3 contributes to converting the activated receptor signal into appropriate cellular responses.
Altered GNB3 function associates with essential hypertension and obesity. Studies show connections between specific GNB3 polymorphisms and these conditions sometimes indicating variations in response to antihypertensive treatments. GNB3 interacts with components of the signal transduction pathways like the protein PLCB1 which may further elucidate its role in disease mechanisms. Understanding these interactions could enhance therapeutic strategies targeting related diseases.