Abcam, ab154869, Anti-APOL3 antibody [EPR8238(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal APOL3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8238(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
APOL3 also known as Apolipoprotein L3 is a protein with a mass of approximately 40 kDa. It belongs to the apolipoprotein family which plays a role in lipid metabolism. APOL3 is expressed mainly in vascular tissues and immune system cells. Its primary mechanical function involves lipid transportation and regulation within cellular compartments contributing to maintaining cellular lipid homeostasis.
Biological function summary
APOL3 operates as part of a complex involved in cellular lipid transport processes. This protein participates in trafficking lipids within cellular membranes and organelles impacting cell membrane dynamics. APOL3 gene expression varies in different tissues influencing how cells manage and utilize lipid molecules. It associates with cellular stress responses especially during pathogen invasions aiding immune system efficiency.
Pathways
APOL3 plays a role in lipid metabolism pathways and immune regulatory pathways. The protein interacts with components of these pathways such as apolipoprotein L family members and enzymes involved in lipid processing. Its activity in these pathways modulates lipid transport and immune responses interacting with components like cholesterol transport proteins and immune receptors. APOL3 contributes to maintaining lipid balance and promoting cellular defense mechanisms.
APOL3 shows a connection to cardiovascular diseases and autoimmune disorders. Abnormalities in its expression can contribute to the lipid dysfunctions associated with atherosclerosis. It also relates to the immune dysregulation observed in certain autoimmune conditions. APOL3 interacts with other apolipoproteins and immune regulatory proteins influencing disease progression and severity. Understanding its role in these contexts can guide therapeutic strategies targeting lipid and immune system abnormalities.