Abcam, ab154954, Anti-RTKN/Rhotekin antibody

Size: 100µL
Rabbit Polyclonal RTKN/Rhotekin antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RTKN aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RTKN aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9BST9

Product details:
Keep as concentrated solution.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Rhotekin also known as RTKN is a scaffold protein with a molecular mass of approximately 62 kDa. It interacts with Rho GTPases facilitating the assembly of signaling complexes. Expressed in various tissues RTKN displays high levels of expression in liver and kidney tissues. Alternative splicing of RTKN results in multiple transcript variants.
Biological function summary
RTKN modulates several cellular processes by influencing cytoskeletal organization. This protein is a part of a Rho GTPase signaling complex that plays roles in cellular morphology and movement. It binds to activated Rho which leads to inhibition of Rho-associated kinase (ROCK) an important regulator of actin structures. This binding stabilizes RTKN's influence on cytoskeletal arrangement.
Pathways
Cellular processes worldwide involve Rho GTPase signals where RTKN plays an important role. It links to the Wnt signaling pathway pivotal for cell proliferation and differentiation through its interaction with Dishevelled proteins. RTKN functions alongside related proteins like ROCK within these pathways. These interactions influence signal transduction and cellular responses.
RTKN shows associations with various cancers including gastric cancer through its interactions with aberrant Rho GTPase activity. Moreover RTKN has implications in neurodegenerative diseases like Alzheimer's often involving disrupted Rho signaling alongside proteins like tau. These connections highlight RTKN's importance in disease progression and make it a potential therapeutic target.