Abcam, ab154969, Anti-GPBB antibody

Size: 100µL
Rabbit Polyclonal GPBB antibody. Suitable for IHC-P, WB and reacts with Mouse, Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Glycogen phosphorylase, brain form aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Glycogen phosphorylase, brain form aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P11216

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein generally known as GPBB (glycogen phosphorylase brain form) plays a critical role in glucose metabolism. An alternate name for this protein is brain-type glycogen phosphorylase. The GPBB protein weighs approximately 97 kDa. It is mainly expressed in the brain but also present in skeletal and cardiac muscle tissues. This enzyme catalyzes the breakdown of glycogen into glucose-1-phosphate an essential step in energy production particularly during periods of increased cellular energy demand.
Biological function summary
GPBB contributes significantly to cellular energy homeostasis. It often partners with AMP-activated protein kinase (AMPK) among other proteins acting as a part of cellular complexes that regulate energy metabolism. GPBB is essential in maintaining the balance between glycogen synthesis and degradation ensuring that glucose levels rise during energy-demanding activities. This regulation supports proper brain function especially in neurons which heavily rely on glucose as an energy source.
Pathways
GPBB is fundamental in the glycogenolysis pathway which mobilizes glucose from glycogen reserves during metabolic needs. GPBB also relates to the insulin signaling pathway influencing how cells respond to insulin a protein vital for glucose uptake and metabolism. Through these pathways GPBB interacts with other proteins like glycogen synthase and phosphoglucomutase establishing a network that carefully coordinates metabolic responses to varying energy availability.
GPBB has significant implications in cardiac ischemia and neurodegenerative disorders such as Alzheimer's disease. During cardiac ischemia elevated levels of GPBB often indicate heart damage given its role in glycogen breakdown in cardiac muscle cells. In Alzheimer's disease abnormal GPBB activity might affect neuronal energy balance contributing to the disease's progression. Understanding these connections is important for developing therapeutic approaches targeting metabolic pathways involving GPBB.