Abcam, ab155084, Anti-PHOX2A antibody [EPR9071]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PHOX2A antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9071,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please
contact us
for more information.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PHOX2A also known as Arix among other names is a transcription factor with an approximate mass of 34 kDa. It plays an essential role in the development of the autonomic nervous system. PHOX2A shows specific expression in neuronal tissues particularly in the noradrenergic and cholinergic neurons. Its function involves the regulation of genes that control neuronal differentiation and development.
Biological function summary
PHOX2A is key in the regulation of noradrenergic phenotype important for the formation and maintenance of the autonomic nervous system. It interacts as part of a transcriptional complex working directly to activate the expression of genes necessary for the synthesis of catecholamines such as dopamine beta-hydroxylase. The protein ensures the proper differentiation of neural crest cells into sympathetic and parasympathetic neurons by influencing its genetic targets.
Pathways
PHOX2A is integral to the development of the autonomic nervous system pathway and the noradrenergic biosynthesis pathway. Much of its function is orchestrated through interactions with other transcription factors like PHOX2B. By regulating gene expression within these pathways PHOX2A contributes to the broader network of neural crest cell development impacting cellular processes that underpin nervous system formation and function.
Mutations in PHOX2A have been linked to congenital central hypoventilation syndrome and Hirschsprung disease. In these conditions PHOX2A's relationships with other proteins notably PHOX2B are significant as these proteins share overlapping roles in neural development. Disruptions in PHOX2A consequently impair pathways and processes critical for autonomic control and gut innervation leading to the aforementioned disorders.