Abcam, ab155094, Anti-RHAG antibody [EPR10011]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RHAG antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10011,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The RHAG protein also known as the Rh-associated glycoprotein or Rh family C glycoprotein has a molecular mass of approximately 50000 Daltons. It is present mainly on erythrocyte membranes and works as a part of the Rh blood group system. RHAG acts as an ammonium transporter enabling the movement of ammonia and possibly CO2 across the cell membrane though exact specifics of its mechanisms are not completely clear.
Biological function summary
The RHAG protein is part of the Rh complex within the erythrocyte membrane which also includes RhD and RhCE proteins. This complex contributes to the structural integrity of the red cell membrane and plays an important role in maintaining the biconcave shape of the erythrocytes which is necessary for optimal oxygen exchange and gas transport. RHAG's function is essential for normal erythrocyte operation and overall cellular homeostasis.
Pathways
RHAG participates in the ammonia transport pathway and is linked to the Rh protein complex pathway. It interacts closely with proteins like RhD and RhCE working together to facilitate membrane stability and function in red blood cells. These interactions within the pathways emphasize RHAG's role in gas transport-related functions and metabolic waste management in the bloodstream.
Defects in RHAG expression or function lead to conditions like Rh-null syndrome and hereditary stomatocytosis. This syndrome characterized by a lack of all Rh antigens on red blood cells often associates with hemolytic anemia due to the compromised integrity of the erythrocyte membrane. Mutations in RHAG also relate to interactions with other proteins like SLC4A1 another important protein involved in red blood cell homeostasis enhancing the complexity and clinical significance of the RHAG protein in health and disease contexts.