Abcam, ab155543, Anti-PSTPIP2 antibody

Size: 100µL
Rabbit Polyclonal PSTPIP2 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSTPIP2 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PSTPIP2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H939

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSTPIP2 also known as proline-serine-threonine phosphatase-interacting protein 2 is a cytosolic adaptor protein with a mass of approximately 48 kDa. This protein is mainly expressed in immune cells particularly in macrophages. Mechanically PSTPIP2 interacts with phosphatases and plays a role in actin cytoskeleton dynamics. It binds to filamentous actin influencing cell shape and motility. Its interactions with tyrosine phosphatases impact signal transduction processes in the cells where it's expressed.
Biological function summary
PSTPIP2 acts as a regulatory molecule that influences inflammation and immune responses. It is a component of molecular complexes that mediate cytoskeletal rearrangement. PSTPIP2 modulates signaling pathways that are important for the activation and differentiation of immune cells. It has a role in limiting excessive inflammatory responses serving as a checkpoint in immune cellular functions.
Pathways
PSTPIP2 is a part of processes involving the regulation of actin dynamics and signal transduction in immune cells. It operates in the Rho GTPase pathway working with proteins like CDC42 which affects cell migration and immune response modulation. PSTPIP2 is also involved in pathways that regulate cytokine signaling influencing inflammatory responses and interacting with several kinases that are essential in this process.
PSTPIP2 has associations with inflammatory conditions such as autoinflammatory diseases. Mutations or dysregulation of this protein link to disorders like chronic recurrent multifocal osteomyelitis. It interacts with proteins involved in inflammation such as the pyrin protein and alterations in PSTPIP2 function can impact the regulatory processes that keep inflammation in balance leading to disease development.