Abcam, ab155579, Anti-CD21+CD35 antibody [7E9]

Size: 100µg
Rat Monoclonal Cr2 antibody. Suitable for IP, Flow Cyt, WB, ICC/IF and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Mouse Cr2.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:7E9,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, IP, ICC/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Mouse Cr2. The exact immunogen used to generate this antibody is proprietary information.P19070,
Specificity:ab155579 does not inhibit rosette formation between 2PK3 cells and Crd-coated SRBC indicator cells.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CD21+CD35 target commonly known as CD21/CD35 includes two surface proteins: CD21 and CD35. CD21 also known as complement receptor 2 (CR2) has an approximate mass of 145 kDa. CD35 also called complement receptor 1 (CR1) varies in mass between 190 to 280 kDa due to glycosylation. These proteins are expressed on the surface of B cells dendritic cells and some epithelial cells. Both markers participate in the immune system aiding in the clearance of pathogens and foreign antigens.
Biological function summary
CD21 and CD35 mediate the binding and clearance of opsonized antigens. These proteins form part of larger complexes where they act as receptors for complement proteins like C3d and C4b. CD21 enhances B cell activation by bridging the B-cell receptor with C3d-bound antigens. Meanwhile CD35 helps clear immune complexes reducing inflammation and facilitating healing.
Pathways
CD21/CD35 plays a significant role in the complement cascade and immune complex clearance pathways. Both CD21 and CD35 connect to other complement proteins such as C3. CD21 also interacts with proteins like CD19 and CD81 forming part of the B-cell co-receptor complex which amplifies B-cell receptor signaling and assists in immune response regulation.
CD21/CD35 involvement links with autoimmune conditions such as systemic lupus erythematosus and chronic lymphocytic leukemia. In these diseases defective or altered CD21/CD35 expression can lead to inadequate immune complex clearance or abnormal B cell activation. Dysfunction in this system may alter interactions with proteins like CD19 contributing to disease progression.