Abcam, ab155593, Anti-TRAP80 antibody

Size: 100µL
Rabbit Polyclonal TRAP80 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MED17 aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MED17 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NVC6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRAP80 also known as Mediator complex subunit 13 (MED13) or Thyroid Hormone Receptor-Associated Protein 80 kDa (THRAP80) plays an essential role in transcription regulation. It is a part of the Mediator complex and has a molecular mass of approximately 80 kDa. TRAP80 functions as a bridge connecting transcriptional activators bound at enhancer regions to the RNA polymerase II machinery enabling transcription initiation. Expression of TRAP80 occurs in various human tissues including heart brain and liver where it mediates gene expression responsive to hormonal signals.
Biological function summary
TRAP80 is involved in regulating gene expression by modifying the chromatin structure which impacts transcription by making specific genes accessible or inaccessible to RNA polymerase II. As a part of the Mediator complex TRAP80 participates in facilitating interactions between enhancers and promoters influencing transcription rates. Through these actions TRAP80 impacts processes like cell growth differentiation and response to external signals and it maintains proper cellular function by regulating gene networks.
Pathways
TRAP80 notably engages in the Wnt signaling pathway and thyroid hormone signaling pathway where it helps modulate transcriptional responses by activating or repressing target genes. In the Wnt pathway TRAP80 works with beta-catenin an important mediator to regulate target gene expression linked with cellular proliferation and differentiation. In the thyroid hormone pathway TRAP80 works in concert with thyroid hormone receptors to mediate the biological effects of thyroid hormones influencing metabolism and development.
TRAP80 has associations with cancer and congenital heart defects. TRAP80's involvement in cancer relates to its role in misregulated transcription pathways that drive oncogenesis. It impacts cancers by facilitating mutations that change normal cell growth and differentiation signals. Additionally in congenital heart defects disturbances in the pathways involving TRAP80 can lead to improper cardiac development. MED13 as a part of the same complex has been studied in connection with these diseases highlighting the importance of the Mediator complex in disease pathology.