Abcam, ab155603, Anti-TAOK2 antibody

Size: 100µL
Rabbit Polyclonal TAOK2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TAOK2 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TAOK2 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q9UL54

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAOK2 a serine/threonine-protein kinase also known as TAO2 is a member of the thousand and one amino acid kinases family. It is a 130 kDa protein that participates in various cellular processes by transferring phosphate groups to serine and threonine residues on substrate proteins. TAOK2 is part of the cytoplasmic signaling pathway and shows expression in different tissues especially in the brain. It plays important roles by interacting with cellular machinery to perform its functions effectively within the cell.
Biological function summary
TAOK2 is instrumental in modulating cytoskeletal dynamics impacting processes such as neuron morphology and dendritic branching. TAOK2 associates with complexes involved in microtubule assembly influencing cell division and intracellular transport. Its activity affects neuronal connectivity impacting neural development and synaptic function which are critical in the nervous system. This makes its regulation necessary for normal brain function and development.
Pathways
TAOK2 integrates into the MAPK signaling pathway affecting cell responses to stress and cytokines. This pathway is important for initiating cellular responses to external stimuli such as changes in the environment or cellular damage. TAOK2 phosphorylates other proteins such as MEK3 MEK6 and p38 MAP kinases influencing downstream signaling cascades. It also interacts with proteins involved in the Wnt signaling pathway contributing to cell differentiation proliferation and the maintenance of stem cells.
TAOK2 has links to neurodevelopmental disorders and schizophrenia. Mutations and dysregulations in TAOK2 expression correlate with developmental abnormalities in the brain potentially leading to conditions like autism spectrum disorder. Furthermore its interaction with proteins such as DISC1 a schizophrenia-associated protein suggests a role in psychiatric disorders. TAOK2's involvement in altering neural architecture highlights its importance in maintaining neuropsychiatric health.