Abcam, ab156011, Anti-ZNRF2 antibody [EPR11399(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ZNRF2 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11399(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The zinc and ring finger protein 2 (ZNRF2) also known as RNF202 is an E3 ubiquitin-protein ligase with significant roles in protein regulation. It has a molecular mass of approximately 37 kDa. ZNRF2 is expressed across various tissues with higher levels found in neural tissues such as the brain. It mainly localizes in the cytoplasm and contributes to the ubiquitin-proteasome pathway aiding in protein degradation by tagging substrates with ubiquitin molecules.
Biological function summary
ZNRF2 functions as part of the cellular apparatus that manages protein homeostasis. It contains a RING finger domain which facilitates its interaction with ubiquitin-conjugating enzymes necessary for its ligase activity. While not always functioning in a complex ZNRF2 often engages with different protein partners to exert its ubiquitination roles in neurons and other cells. This activity influences various cellular processes including neural signal transduction and synaptic plasticity which are important for maintaining nerve cell function and integrity.
Pathways
ZNRF2 interfaces with the ubiquitin-proteasome system and the neural development pathways. It associates with proteins such as neurofilament light polypeptide (NEFL) and neighbors in signaling cascades involving neural growth and repair. It's essential for pathways regulating synaptic function providing a check on protein turnover which informs signal transduction pathways. Consequently its action is critical in controlling the cellular response to external stimuli and internal signals.
Dysregulation of ZNRF2 is implicated in neurodegenerative diseases particularly Alzheimer's disease. Its involvement in protein homeostasis and degradation means that any dysfunction can exacerbate the aggregation of misfolded proteins a hallmark of neurodegeneration. Additionally ZNRF2 associates with the regulation of protein processes involving Tau a protein that forms neurofibrillary tangles in Alzheimer's pathology. Understanding ZNRF2's pathways and interactions paves the way for potential therapeutic targets in treating such disorders.