Abcam, ab156014, Anti-Map17 antibody [EPR10372]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Map17 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10372,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Map17 also known as PDZK1IP1 or MCFD2 functions as a membrane-associated protein with a mass of approximately 17 kDa. It localizes primarily in the plasma membrane but can also be found in other cellular compartments. This protein is expressed in various tissues with high levels observed in renal and gastrointestinal tract tissues. Its structural characteristic includes a PDZ-binding motif which suggests interactions with PDZ domain-containing proteins playing a role in facilitating membrane transport processes.
Biological function summary
The membrane-associated protein Map17 enhances ion conductivity across the cell membrane contributing to fluid transport and cellular homeostasis. It is not part of a documented protein complex but it interacts with scaffolding proteins influencing cellular architecture and function. Map17 also links with cellular redox states regulating the balance between cellular oxidants and antioxidants. Due to its role in ion transport and cellular balance Map17 impacts various physiological processes within the body.
Pathways
Research indicates Map17 involvement in oxidative stress and ion transport pathways. It plays a part in the sodium-potassium transport pathway through interaction with proteins like CFTR and sodium channels affecting fluid balance and kidney function. Furthermore its role in oxidative stress pathways implicates it in cellular responses to reactive oxygen species where Map17 influences proteins like Nrf2 an important regulator of antioxidant defenses. These pathways show how Map17 integrates into broader signaling networks that manage cellular environment and stress responses.
Map17 shows a connection with conditions such as cancer and chronic kidney disease. Research indicates its overexpression in various tumors where it may interact with the oncogene Ras to influence tumor growth and progression. In chronic kidney disease its role in ion transport could contribute to altered renal function with proteins like CFTR also involved in this disease context. Understanding Map17’s involvement in these diseases offers insights into potential therapeutic targets and novel treatment strategies.