Abcam, ab156686, Anti-EXOSC9 antibody

Size: 100µg
Rabbit Polyclonal EXOSC9 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EXOSC9 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EXOSC9 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q06265

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab156686 was affinity purified using an epitope specific to EXOSC9 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EXOSC9 also known as Exosome Component 9 or 3'-5' exoribonuclease CSL4 plays an important mechanical role in RNA processing and degradation. This protein is a component of the exosome complex which is responsible for the controlled breakdown of RNA molecules. The mass of EXOSC9 is approximately 45 kDa. It is expressed in a variety of tissues including brain liver and heart highlighting its importance in diverse cellular activities.
Biological function summary
EXOSC9 functions as a critical element in RNA surveillance and decay pathways within cells. It is a core component of the RNA exosome complex which consists of multiple proteins working together to process and degrade various types of RNA such as rRNA mRNA and small RNAs. The exosome complex plays a significant role in maintaining RNA stability and quality control within eukaryotic cells ensuring the accurate regulation of gene expression.
Pathways
EXOSC9 participates in essential processes involving RNA processing and decay. It is a part of the RNA decay pathway which is vital for the degradation of defective RNA molecules therefore preventing potential cellular dysfunction. EXOSC9 also interacts with proteins like EXOSC10 and EXOSC2 working collectively within the exosome complex to achieve its functionalities in these pathways. This interaction underlines its participation in the larger context of gene expression regulation.
Improper functioning of EXOSC9 has been linked to neurodegenerative conditions such as pontocerebellar hypoplasia. Such conditions result from defects in RNA processing and degradation leading to cellular dysregulation. EXOSC9 is also connected to specific cardiovascular disorders due to its involvement in RNA metabolism and stability. Additionally its interaction with other exosome components like EXOSC8 and EXOSC3 further connects it to broader pathways involved in these diseases.