Abcam, ab156698, Anti-RRP4 antibody

Size: 100µg
Rabbit Polyclonal RRP4 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human EXOSC2 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EXOSC2 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q13868

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab156698 was affinity purified using an epitope specific to EXOSC2 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RRP4 also known as RRP4 homolog is a component of the exosome complex a multi-protein complex involved in RNA processing. RRP4 plays an important mechanical role in RNA degradation and it is essential for maintaining RNA stability by facilitating the 3' to 5' exonucleolytic trimming of RNA molecules. This protein has a molecular mass of approximately 26 kDa and is widely expressed in the nucleus and cytoplasm where it participates in various RNA processing tasks.
Biological function summary
RRP4 performs an important role in RNA metabolism and is a vital constituent of the exosome complex which is responsible for RNA processing degradation and surveillance. The exosome complex acts in RNA quality control targeting malformed RNAs for degradation. RRP4 contributes to rRNA processing and maturation by forming stable interactions within the nucleolus. This activity ensures the accuracy and functionality of ribosomal RNA supporting the cell's protein synthesis machinery.
Pathways
RRP4 plays a critical function in the RNA processing pathways and is involved in rRNA and mRNA turnover. RRP4 interconnects with pathways involving exosome components like RRP6 and DIS3 which also contribute to RNA decay. Processing of rRNA by mechanisms involving RRP4 ensures the quality of ribosome assembly which is essential for translation and cellular homeostasis.
Improper function of the exosome complex including RRP4 associates with neurological conditions such as pontocerebellar hypoplasia and certain forms of cancer. RRP4 alongside proteins like RRP6 and DIS3 can accumulate mutations affecting exosome functionality. This can lead to disrupted RNA processing and accumulation of faulty RNA products contributing to disease pathogenesis. Understanding these interactions is vital for developing therapeutic approaches targeting such conditions.