Abcam, ab157468, Anti-DLC-A antibody [EPR11240]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DLC-A antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11240,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DLC-A also known as Deleted in Liver Cancer-1 or ARHGEF5 is a Rho guanine nucleotide exchange factor with a mass of approximately 205 kDa. This protein plays a role in cellular processes by activating members of the Rho GTPase family which are key regulators of the cytoskeleton. DLC-A is expressed in various tissues including liver kidney and heart suggesting its broad implication in cellular functions across different organ systems.
Biological function summary
DLC-A acts as a guanine nucleotide exchange factor facilitating the exchange of GDP for GTP on Rho family GTPases. This activity leads to the activation of these GTPases promoting cytoskeletal rearrangements and influencing cell shape motility and growth. DLC-A integrates into large protein complexes interacting with various other signaling molecules that modulate its activity in different cellular contexts highlighting its broad involvement in cell dynamics.
Pathways
Many cellular transformations and regulatory systems involve DLC-A. DLC-A participates in the Rho signaling pathway important for actin cytoskeleton dynamics. It also interacts with the MAPK/ERK pathway which influences cell division and survival. In these pathways DLC-A connects with proteins like RhoA and ERK1/2 showing its pivotal role in signal transduction and cellular responses to external signals.
Genomic alterations and expression changes in DLC-A have links to cancer progression especially in liver cancer. Researchers have found that altered DLC-A expression affects tumor formation and metastasis through its action in cytoskeletal remodeling and cell movement. Furthermore DLC-A relates to cardiovascular disorders due to its significant effects on vascular cell function. In these contexts DLC-A interacts with other proteins like PI3K and Akt which are involved in cell proliferation and survival emphasizing its role in disease etiology.