Abcam, ab158238, Recombinant Human Cathepsin W protein

Size: 10µg
Recombinant Human Cathepsin W protein is a Human Full Length protein, in the 22 to 376 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P56202,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cathepsin W also known as CTSW is a member of the cysteine protease family. It has a molecular mass of approximately 45 kDa and functions as an enzyme that breaks down protein substrates through proteolysis. CTSW displays specificity for certain peptide bonds in its target proteins. This protein is mostly expressed in the immune system especially in cytotoxic T cells and natural killer cells. The expression pattern suggests its involvement in immune responses.
Biological function summary
Cathepsin W contributes to the modulation of cytotoxic activity. It assists in the rearrangement and processing of proteins important for the immune response facilitating the proper functioning of immune effector cells. While not part of a specific protein complex CTSW activity aligns with immune cell regulation mechanisms. Its role in the degradation of proteins plays a significant part in maintaining immune cell competency.
Pathways
Cathepsin W contributes to the immune response and apoptosis. The immune response pathway involves cytotoxic T cells and natural killer cells where CTSW enhances the degradation of target proteins. In apoptosis the protein functions in the breakdown of cellular components that need recycling or removal. Cathepsin W shares functional similarities with related proteases such as Cathepsin C which also participates in immune cell regulation and apoptosis.
Cathepsin W has relevance in immunological diseases and some cancer types. Altered activity of CTSW may associate with impaired immune responses contributing to immunodeficiency conditions. In certain cancers such as leukemia changes in CTSW expression could influence the behavior of tumor-infiltrating lymphocytes. Proteins like granzyme B which are involved in inducing apoptosis might interact with CTSW reflecting their shared pathways in modulating immune responses and disease progression.