Abcam, ab158648, Recombinant Human Orexin Receptor 1/Ox-1-R protein

Size: 10µg
Recombinant Human Orexin Receptor 1/Ox-1-R protein is a Human Full Length protein, in the 1 to 425 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O43613,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Orexin Receptor 1 also known as Ox-1-R or Ox protein is a G-protein-coupled receptor that binds to orexin A peptides. The receptor has a mass of approximately 50 kDa and is expressed in various brain regions including the hypothalamus. Its presence is notable in areas involved in arousal and regulation of sleep-wake cycles. Through binding to its ligands Ox-1-R activates intracellular signaling cascades by coupling with G-proteins contributing to the modulation of neurotransmission and neuronal excitability.
Biological function summary
Orexin receptors regulate energy homeostasis and alertness. Ox-1-R is involved in the control of wakefulness and appetite as it interacts with neurotransmitters such as noradrenaline and histamine. Ox-1-R does not function in isolation; it works in tandem with other receptors and proteins including orexin receptor 2 to form integrated networks for maintaining physiological balance. Their role in the central nervous system is essential for coordinating physical and mental activity.
Pathways
Orexin 1 receptor participates in the neuropeptide signaling pathways and sleep regulation mechanisms. Orexin receptors take part in the hypothalamic neuropeptide pathways interacting with other proteins like melanin-concentrating hormone and corticotropin-releasing factor facilitating the control of sleep and feeding cycles. These interactions underline the receptor’s regulatory functions on metabolic and circadian rhythm processes ensuring organismal adaptation to varying environmental cues.
Orexin 1 receptor dysfunction associates with sleep disorders such as narcolepsy and conditions like obesity. Reduced activity of Ox-1-R can contribute to narcolepsy a chronic neurological disorder characterized by excessive daytime sleepiness and cataplexy. In obesity dysregulation of the orexin signaling might influence energy balance and appetite linking it with metabolic disorders. Related proteins in these conditions include orexin receptor 2 and neuropeptide Y indicating a broader network of interactions affecting these disease states.