Abcam, ab158661, Recombinant Human MR1 protein

Size: 10µg
Recombinant Human MR1 protein is a Human Fragment protein, in the 201 to 300 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q95460,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MR1 also known as the MR1 receptor or MR1 protein is an important player in the immune system. It weighs around 37 kilodaltons. This protein expresses prominently in many tissues such as the liver lymphoid tissues and the intestine. MR1 binds a range of small molecules derived from vitamin B metabolites. It presents these metabolites to a specific group of immune cells known as mucosal-associated invariant T (MAIT) cells leading to their activation.
Biological function summary
MR1 varies its mechanism by forming complexes with antigens that lack traditional peptide structure. It performs a major role in the immune response particularly through its interactions with MAIT cells. These cells represent an important intersection between innate and adaptive immunity responding rapidly to many pathogen-associated metabolites presented by MR1. This response contributes importantly to host protection especially against microbial infections.
Pathways
MR1 is an integral component in the vitamin B antigen presentation pathway. It interacts significantly with other molecules involved in antigen presentation. MR1's function anchors it within the host-pathogen interaction pathways and connects with proteins like beta-2-microglobulin (β2M) which is important for surface expression. Its activity complements classical MHC pathways although it operates independently in presenting non-peptide antigens.
MR1 contributes to understanding certain autoimmune conditions and infectious diseases. It connects to infectious diseases such as tuberculosis where MAIT cell activation plays a critical role in the immune response. Additionally MR1 has links to inflammatory bowel disease (IBD) a condition where gut microbiota activation of MAIT cells through MR1 may influence the disease outcome. Understanding its role in these diseases can provide insights into how MR1 or related proteins might be targeted for therapeutic interventions.