Abcam, ab158774, Recombinant Human Integrin alpha 9 protein

Size: 10µg
Recombinant Human Integrin alpha 9 protein is a Human Fragment protein, in the 785 to 886 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q13797,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin alpha 9 also known as alpha-nine or alpha-9 is a transmembrane protein that is part of the integrin family. It typically forms dimer with beta-1 integrin subunit. This protein has an approximate mass of 150 kDa. Integrin alpha 9 is expressed in various tissues with notable levels in the epithelial cells smooth muscle cells and leukocytes. Its primary mechanical role involves mediating cell adhesion and signaling by interacting with the extracellular matrix (ECM) components and some specific ligands.
Biological function summary
Integrin alpha 9 influences cell migration proliferation and survival through its interactions with ECM proteins like tenascin-C and osteopontin. It does not function alone; it forms part of a complex that includes various signaling molecules and cytoskeletal proteins. These associations facilitate communication between the cell cytoskeleton and the ECM influencing processes like wound healing and inflammation.
Pathways
Integrin alpha 9 plays roles in pathways such as the integrin signaling pathway and the focal adhesion pathway. It interacts closely with molecules like focal adhesion kinase (FAK) and Paxillin which are critical within these pathways. These relationships allow integrin alpha 9 to modulate cellular responses such as spreading migration and cellular structural organization.
Integrin alpha 9 has connections with conditions such as asthma and cancer. In asthma its interaction with ECM proteins contributes to inflammation and airway remodeling. In cancer altered expression and signaling through integrin alpha 9 can influence tumor growth and metastasis. The protein's involvement in disease processes often interacts with other integrins and receptors that regulate inflammation and cellular migration such as certain cytokine receptors.