Abcam, ab15895, Anti-VDAC1/Porin + VDAC2 + VDAC3 antibody – Mitochondrial Loading Control

Size: 100µg / 250µg
Anti-VDAC1/Porin + VDAC2 + VDAC3 antibody – Mitochondrial Loading Control (ab15895) is a rabbit polyclonal antibody detecting VDAC1/Porin in Western Blot, IHC-P, ICC/IF . Suitable for Chicken, Chinese hamster, Cow, Dog, Human, Mouse, Rat . - Over 390 publications - Trusted since 2005
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Chinese hamster, Mouse, Rat, Dog, Chicken, Human, Cow,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody detects VDAC1, VDAC2 and VDAC3.

Product details:
Anti-VDAC1/Porin + VDAC2 + VDAC3 antibody – Mitochondrial Loading Control (ab15895) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human, mouse, rat samples.
Anti-VDAC1/Porin + VDAC2 + VDAC3 antibody – Mitochondrial Loading Control (ab15895) has been cited over 398 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-VDAC1/Porin + VDAC2 + VDAC3 antibody – Mitochondrial Loading Control (ab15895) has high sensitivity and specificity.
Anti-VDAC1/Porin + VDAC2 + VDAC3 antibody – Mitochondrial Loading Control (ab15895) has 33 independent reviews from customers.
Anti-VDAC1/Porin + VDAC2 + VDAC3 antibody – Mitochondrial Loading Control (ab15895) specifically detects VDAC1/Porin; VDAC2; VCAD3 (UniProt ID: P21796; Molecular weight: 31kDa) and is sold in 100 µg and 250 µg selling sizes.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The VDAC family also known as porins includes the isoforms VDAC1 VDAC2 and VDAC3. These proteins are integral components of the outer mitochondrial membrane and play key roles in cellular metabolism and energy production. VDAC1 the most studied isoform has a molecular mass of approximately 31 kDa. These proteins facilitate the transfer of metabolites ions and ATP between the mitochondria and the cytoplasm therefore regulating mitochondrial function. They are expressed in various tissues throughout the body reflecting their fundamental role in cellular functions.
Biological function summary
VDAC proteins serve as gatekeepers for mitochondrial channels controlling the passage of molecules into and out of mitochondria. They are part of a large complex that includes proteins like hexokinase creatine kinase and components of the mitochondrial permeability transition pore. VDACs significantly influence apoptosis by participating in the release of cytochrome c a critical step in the apoptotic pathway. Their function affects cellular survival energy balance and metabolism.
Pathways
The VDAC proteins are closely associated with energy metabolism and apoptotic pathways. They interact with the electron transport chain and glycolysis by regulating substrate flow and maintaining mitochondrial membrane potential. VDACs also link to Bcl-2 family proteins which modulate apoptosis. Their role in maintaining cellular homeostasis emphasizes their importance in cellular life-and-death decisions impacting vital processes such as oxidative phosphorylation and ATP synthesis.
Alterations in VDAC function have been linked to cancer and neurodegenerative diseases. In cancer increased VDAC expression is often associated with enhanced glycolysis and tumor growth. VDACs regulate interactions with proteins like hexokinase which promotes cancer cell survival. In neurodegenerative diseases such as Alzheimer’s dysfunctional VDAC activity can lead to impaired mitochondrial function and increased oxidative stress. These changes involve interactions with proteins like tau and amyloid-beta contributing to disease pathology.