Abcam, ab159622, Recombinant Human ADA2a protein

Size: 10µg
Recombinant Human ADA2a protein is a Human Full Length protein, in the 1 to 305 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O75478,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADA2a also known as adenosine deaminase 2 possesses a molecular mass of approximately 55 kDa. It is an enzyme that catalyzes the hydrolytic deamination of adenosine converting it into inosine. ADA2a primarily localizes in extracellular regions and is secreted by immune cells such as monocytes and macrophages. The enzyme has notable expression in tissues like the spleen small intestine and liver.
Biological function summary
The hydrolytic activity of ADA2a contributes to the modulation of immune responses. The enzyme regulates extracellular levels of adenosine a molecule with immunosuppressive properties thereby influencing inflammation and immune activation. Furthermore ADA2a is associated with the monocyte and macrophage activation process and interacts with other proteins as part of immune system complexes. This interaction allows ADA2a to play a role in regulating immune cell function and communication.
Pathways
ADA2a operates within the purine metabolism pathway where it functions to maintain nucleoside balance. It also contributes to the regulation of immune signaling pathways. The enzyme interacts with other metabolic enzymes like adenosine kinase which further modulate adenosine levels and influence immune cell proliferation and differentiation. These interactions place ADA2a as an important player within these pathways exerting influence on the immune response and cellular metabolism.
ADA2a has been linked to conditions such as systemic inflammation and immunodeficiency disorders. The enzyme is involved in disorders like deficiency of adenosine deaminase 2 (DADA2) which results in vascular and immune dysfunction. ADA2a interacts with proteins like tumor necrosis factor (TNF) in these pathological contexts influencing the course of disease through its regulatory effects on inflammation and immune responses. Understanding its role opens potential avenues for therapeutic intervention in related conditions.