Abcam, ab160523, Recombinant Human MPPB protein

Size: 10µg
Recombinant Human MPPB protein is a Human Full Length protein, in the 1 to 490 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O75439,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
This product was previously labelled as PMPCB.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MPPB also known as multi-purpose binding protein has a mass of approximately 55 kDa. This protein is expressed in various tissues including liver brain and muscle. MPPB plays a role in binding multiple partners facilitating interactions between proteins and stabilizing complexes. The multi-functional nature of MPPB allows it to assist in a range of cellular processes by providing structural and logistical support to its binding partners.
Biological function summary
The multi-functional binding protein assists in cellular communication and intracellular transport. MPPB often forms part of a larger protein complex allowing it to regulate the assembly and disassembly of its components. It contributes to the maintenance of cellular structure and plays a role in signaling pathways by modulating interactions with signaling molecules. Due to its integral function disruptions in MPPB can lead to alterations in cellular function and organization.
Pathways
MPPB participates in key cellular pathways such as the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K) pathway. These pathways are important for cell growth survival and differentiation. MPPB interacts with proteins like RAF1 and AKT influencing their activity and thereby regulating downstream signaling events. By connecting and modulating these pathways MPPB maintains cellular homeostasis and directs cellular responses to external stimuli.
Multi-purpose binding protein involvement has been associated with cancer and neurodegenerative disorders. Abnormal expression or function of MPPB has shown links to tumor growth possibly by altering the MAPK or PI3K pathways. In neurodegenerative diseases MPPB might interact with proteins like tau impacting cellular stability and neural function. By understanding these interactions researchers can better target MPPB for potential therapeutic interventions in these conditions.