Abcam, ab160571, Recombinant Human RAB36 protein

Size: 10µg
Recombinant Human RAB36 protein is a Human Full Length protein, in the 1 to 333 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O95755,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RAB36 is a member of the RAS oncogene family and functions mechanically as a small GTPase a protein that binds and hydrolyzes guanosine triphosphate (GTP). It is often abbreviated as member RAS oncogene family 36 in literature. This protein has a molecular mass of approximately 35 kDa. RAB36 is expressed in various tissues including the brain where it plays a significant role in intracellular signaling and transport processes.
Biological function summary
RAB36 regulates intracellular vesicle trafficking which is essential for proper cellular function. It does this by controlling vesicle movement along cytoskeletal tracks and facilitating the fusion of vesicles with their target membranes. RAB36 operates independently not forming part of any known complex but it might interact with other proteins that contribute to the same biological processes in the cell.
Pathways
RAB36 participates in the regulation of membrane trafficking pathways which are fundamental for cellular homeostasis and communication. These pathways indicate its association with proteins such as RAB7 and RAB9 both of which are also part of the RAB family and share roles in vesicular transport. RAB36 is particularly addressed in exocytic pathways influencing the delivery of proteins and lipids to the cell surface.
Alterations in RAB36 expression or function can link to disorders of intracellular trafficking like neurodegenerative diseases and cancer. Incorrect vesicle transport and fusion may contribute to the pathology of these conditions. Additionally proteins like RAB7 which is associated with RAB36 also relate to similar disorders highlighting the importance of proper regulation of the RAB family in disease prevention.