Abcam, ab160875, Recombinant Human CRLR protein

Size: 10µg
Recombinant Human CRLR protein is a Human Full Length protein, in the 1 to 461 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q16602,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Calcitonin Receptor-Like Receptor (CRLR) also known as the calcitonin receptor-like receptor functions as a G-protein-coupled receptor involved in the regulation of various physiological processes. CRLR has a molecular mass of approximately 55 kDa. This receptor is broadly expressed in numerous tissues including the cardiovascular system the central nervous system and peripheral tissues. As a receptor CRLR plays a central role in signal transduction by binding to specific peptide ligands mainly through interaction with receptor activity-modifying proteins (RAMPs) which are essential for its functional specificity.
Biological function summary
CRLR operates as part of a receptor complex with RAMPs that determines its ligand specificity; this complex enables it to bind peptides such as adrenomedullin and calcitonin gene-related peptide (CGRP). When combined with different RAMPs CRLR can switch its ligand affinity and function as adrenomedullin or CGRP receptors therefore influencing vascular tone pain transmission and metabolic regulation. Research demonstrates that CRLR and its associated complexes contribute to processes like vasodilation angiogenesis and neurogenic inflammation emphasizing its role in maintaining homeostasis.
Pathways
CRLR actively participates in critical biological pathways particularly the signaling pathways of CGRP and adrenomedullin which are significant in cardiovascular and nervous system functions. Within these pathways CRLR modulates the activity of secondary messengers such as cyclic AMP (cAMP) upon ligand binding therefore initiating further downstream effects in target cells. Related proteins including RAMPs and components of cAMP signaling work in conjunction with CRLR to ensure precise cellular responses to ligand stimulation linking it to broader physiological processes like stress response and blood pressure regulation.
CRLR stands associated with conditions such as migraines and heart failure. The ability of CRLR to bind CGRP makes it a target for migraine therapies as CGRP plays a pivotal role in migraine pathophysiology. Additionally CRLR through its regulation of adrenomedullin becomes linked to heart failure given adrenomedullin's effects on vasodilation and cardiac function. In these pathological conditions CRLR often interacts with RAMPs influencing the severity and progression of the disease capturing interest for therapeutic interventions.