Abcam, ab161039, Recombinant Human JWA protein

Size: 10µg
Recombinant Human JWA protein is a Human Fragment protein, in the 1 to 64 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O75915,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JWA also known as GTRAP3-18 or ADDCL is a protein with a molecular mass of approximately 37 kDa. Mechanically JWA functions in detoxification processes as it enhances the capacity of cells to combat oxidative stress. This protein exhibits a wide expression pattern across various tissues including the liver and the nervous system. JWA operates in both the cytoplasm and nucleus and dynamically shuttles between these cellular compartments.
Biological function summary
JWA interacts with signaling molecules to modulate cellular responses particularly in stress and repair processes. As a part of multi-protein complexes it collaborates with components like ERK (extracellular signal-regulated kinase) to influence cell survival and proliferation. JWA's involvement extends to regulating cytoskeletal elements affecting cellular movements important for tissue repair and immune responses.
Pathways
JWA integrates into the MAPK/ERK signaling pathway and the ATRA (all-trans retinoic acid) pathway. In these pathways JWA associates with proteins such as MEK1/2 and enhances their activity to promote cell differentiation and combat cellular apoptosis. The interaction of JWA with protein kinases exhibits its integral role in transmitting signaling molecules' instructions necessary for cellular development processes.
JWA shows a connection to cancer and neurodegenerative disorders. In cancer biology JWA's modulation of signaling pathways affects tumor growth interacting with proteins like p53 to induce cell cycle arrest and apoptosis. In the context of neurodegenerative disorders JWA helps mitigate oxidative stress and interacts with proteins involved in neuronal integrity suggesting a protective role against conditions like Alzheimer's disease.