Abcam, ab161181, Recombinant Human NMU protein

Size: 10µg
Recombinant Human NMU protein is a Human Full Length protein, in the 36 to 174 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P48645,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuromedin U (NMU) is a regulatory peptide known for its role in modulating smooth muscle contraction and energy homeostasis. Alternate names include neuromedin reflecting its original discovery in the spinal cord. NMU has a molecular mass ranging between 2392 and 2583 Da depending on the variant. It is expressed predominantly in the gastrointestinal tract and central nervous system influencing various physiological processes within these tissues.
Biological function summary
NMU functions significantly within the nervous and endocrine systems. It is an important part of the larger neuromedin peptide family. NMU interacts with specific receptors NMU-R1 and NMU-R2 to mediate biological effects. Within the body NMU influences feeding behavior circadian rhythms and stress response mechanisms demonstrating its integral role in maintaining physiological balance.
Pathways
NMU integrates into hormonal and neuroendocrine signaling routes. The peptide participates in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis influencing stress responses. Its action also intersects the energy metabolism pathway interacting with proteins such as ghrelin and leptin. These interactions position NMU as an important player in energy intake control and stress regulation.
NMU has implications in obesity and inflammatory diseases. Abnormally high or low levels can contribute to metabolic disorders indicating its central role in energy balance and metabolic health. NMU's connection to the HPA axis associates it with proteins like corticotropin-releasing hormone which impacts inflammatory processes. Exploring NMU's involvement could unveil new therapeutic strategies for managing these conditions.