Abcam, ab161296, Recombinant Human RPP14 protein

Size: 10µg
Recombinant Human RPP14 protein is a Human Full Length protein, in the 1 to 124 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O95059,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPP14 also known as Ribonuclease P/MRP 14 kDa subunit is an enzymatic protein that plays an important role in RNA processing. It has a molecular weight of approximately 14 kDa. This protein is part of the ribonuclease P complex an essential component for the maturation of precursor tRNA molecules by removing 5' leader sequences. RPP14 expresses in a variety of tissues with higher levels often seen in those requiring extensive RNA processing such as the liver and spleen.
Biological function summary
The protein assists in facilitating the correct processing of RNA influencing translation and overall protein synthesis. It forms part of the ribonuclease P complex which contains a catalytic RNA component and multiple protein subunits. The presence of RPP14 within this complex ensures efficient catalytic activity required for precise RNA processing. Alterations in the function or expression of this protein can disrupt RNA maturation influencing cellular function and organism development.
Pathways
RPP14 engages directly within the RNA processing and tRNA maturation pathways. These pathways are critical for maintaining cellular homeostasis by ensuring the production of accurately processed RNA molecules. RPP14 interacts with other proteins in these pathways such as several ribonuclease P RNA subunits and RNase MRP highlighting its role in a larger network of RNA processing entities.
Any disruption in RPP14 function can associate with conditions like ribosomopathy and other disorders impacting cellular RNA metabolism. For example mutations affecting its function have links to skeletal abnormalities due to improper RNA processing. It can also relate to dysfunctions in associated proteins like RPP20 and RPP30 leading to similar manifestations on the molecular and phenotypic levels.