Abcam, ab161722, Recombinant Human Cbl-c protein

Size: 10µg
Recombinant Human Cbl-c protein is a Human Full Length protein, in the 1 to 474 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9ULV8,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cbl-c also known as Casitas B-lineage lymphoma protein C is a member of the Cbl family of ubiquitin ligases. This protein has an approximate mass of 56 kDa and is expressed in various tissues including skeletal muscle and the uterus. Cbl-c functions as an E3 ubiquitin-protein ligase which means it tags target proteins for degradation by the proteasome. By doing so it regulates protein turnover and maintains cellular protein balance.
Biological function summary
Cbl-c interacts with signaling complexes and modulates signal transduction pathways. It participates in processes such as negative regulation of tyrosine kinase signaling. Cbl-c operates alongside other proteins in the Cbl family including Cbl and Cbl-b to downregulate signaling through ubiquitination. It plays a significant role in the regulation of cellular growth and differentiation by targeting specific proteins for degradation.
Pathways
Cbl-c interacts with cellular signaling mechanisms involved in the regulation of growth and cellular response. Cbl-c is an important component of pathways like the Epidermal Growth Factor Receptor (EGFR) signaling pathway and the Insulin signaling pathway. Through these pathways Cbl-c also interacts with receptor tyrosine kinases such as EGFR and insulin receptors impacting cellular processes like proliferation migration and apoptosis.
Mutations or dysregulation of Cbl-c have associations with tumor progression and metabolic disorders. Cancer and insulin resistance are two conditions in which alterations in Cbl-c function contribute to disease pathology. Interactions with proteins such as EGFR and insulin receptor through these disorders highlight Cbl-c’s involvement in critical regulatory networks impacting human health.