Abcam, ab162149, Recombinant Human ProSAAS protein

Size: 10µg
Recombinant Human ProSAAS protein is a Human Fragment protein, in the 173 to 260 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9UHG2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ProSAAS also known as PCSK1N (ProSAAS Neuropeptide) is a protein that acts as an inhibitor of prohormone convertases specifically PC1/3. It weighs approximately 28 kDa. ProSAAS expresses predominantly in neuroendocrine tissues especially in the brain and pancreatic islets. Its expression in these areas implies a significant role in neuroendocrine signaling.
Biological function summary
ProSAAS functions as a neuropeptide precursor influencing the maturation of other peptide hormones. It is not typically considered part of a larger protein complex but interacts with other proteins to modulate their activity. ProSAAS directly inhibits catalytic activity of PC1/3 affecting the processing and sorting of various peptide hormones and neuropeptides critical for proper brain and endocrine system function.
Pathways
Interactions between ProSAAS and its influence in the prohormone processing pathway are significant. It contributes to the regulation of the neuroendocrine signaling pathway. ProSAAS shares a regulatory network with other proteins like prohormone convertase 2 (PC2) emphasizing its role in the complex hormone maturation landscape.
Alteration in ProSAAS expression or function links to metabolic syndromes and neurodegenerative diseases. For metabolic syndromes changes in ProSAAS can impact insulin regulation linking it to diabetes via its interaction with proteins like insulin. In neurodegenerative diseases such as Alzheimer's ProSAAS appears to modulate amyloid-beta peptide formation influencing disease progression in a manner shared with amyloid precursor protein (APP).