Abcam, ab162319, Recombinant Human ST6GALNAC6 protein

Size: 10µg
Recombinant Human ST6GALNAC6 protein is a Human Full Length protein, in the 1 to 333 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q969X2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ST6GALNAC6 also known as ST6 N-acetylgalactosaminide alpha-26-sialyltransferase 6 is an enzyme with an important role in glycosylation processes. It has a molecular mass of about 59 kDa. The enzyme catalyzes the addition of sialic acid to glycoproteins and glycolipids specifically attaching to N-acetylgalactosamine-containing substrates. ST6GALNAC6 is expressed mainly in tissues such as the brain liver and digestive tract where it influences various physiological and biochemical modifications of cellular surfaces.
Biological function summary
ST6GALNAC6 mods glycan structures and affects signal transduction and cell-to-cell interactions. It functions as a part of the sialyltransferase enzyme family altering glycoproteins and glycolipids which impact molecular mechanisms including cellular adhesion and migration. These actions influence cell communication and pathogenesis processes; however it's not known to work as a component of a significant protein complex.
Pathways
ST6GALNAC6 influences the glycoprotein biosynthesis process and the sialylation pathway. It modifies molecules involved in the synthesis and modification of O-linked glycans impacting several proteins for instance mucins due to its role in the sialylation of glycoproteins. The enzyme's activities intersect with pathways involving other key glycosylation enzymes such as ST6GAL1 indicating its integrated role in glycan biosynthesis and cellular signaling cascades.
ST6GALNAC6 contributes to the development of conditions like cancer and cardiovascular diseases. Its altered expression is linked with cancer-related mechanisms due to changes in cell adhesion and metastasis as sialylation impacts how cancer cells interact with their environments. Additionally researchers associate its dysregulation with cardiovascular pathologies through impacts on related proteins such as mucins highlighting its influence on the progression of these diseases.