Abcam, ab162880, Recombinant Human NCAPG2 protein

Size: 10µg
Recombinant Human NCAPG2 protein is a Human Full Length protein, in the 1 to 935 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q86XI2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein NCAPG2 also known as Condensin-2 complex subunit G2 is important to the mechanical processes within cells. It plays an important role in mitosis and is part of the condensin II complex responsible for chromosome condensation and stabilization during cell division. NCAPG2 is a large protein with a mass of around 120 kDa. Expression is predominantly observed in proliferating tissues such as those in the bone marrow and thymus. This wide expression reveals its direct participation in fundamental cellular functions.
Biological function summary
The organism relies on NCAPG2 to ensure accurate chromosome segregation. As a component of the condensin II complex it collaborates with other subunits including NCAPD3 and SMC2. The protein's main task is to maintain the structural integrity of chromosomes allowing proper chromosome alignment during mitosis. This integrity is essential for genomic stability reducing the risks of aneuploidy.
Pathways
NCAPG2 is deeply involved in the regulation of the cell cycle. It takes part in both the mitotic prophase and anaphase pathways. Its function relates closely to other proteins like Cdc2 and Cyclin B which direct the progression of cell division. By integrating with structural pathways of chromosomes NCAPG2 becomes an important element in preventing mitotic errors and preserving cellular fidelity.
NCAPG2 has been linked to carcinogenesis and some developmental disorders. Aberrant expression or dysfunction of NCAPG2 is often observed in certain cancers such as breast and prostate cancer where genomic instability is a common characteristic. In cancerous conditions its interaction with proteins like p53—known for DNA damage response—becomes significant highlighting its potential role in tumorigenesis. Furthermore studies investigate its connection with developmental anomalies probing possible implications in aberrant cellular proliferation pathways.