Abcam, ab162993, Recombinant Human CEP55 protein

Size: 10µg
Recombinant Human CEP55 protein is a Human Full Length protein, in the 1 to 464 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q53EZ4,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP55 also known as centrosome-associated protein 55 or FLJ20808 is a protein with a molecular weight of about 55 kDa. This protein plays a mechanical role in cell division especially during cytokinesis. CEP55 primarily localizes at the centrosome and midbody of dividing cells. Its expression is widespread throughout various tissues though it is especially present in rapidly dividing or proliferating tissues.
Biological function summary
CEP55 contributes significantly to the final stages of cell division by acting as a critical regulator in cytokinesis. It participates in the abscission process which is the final separation phase of two daughter cells. CEP55 helps recruit other proteins necessary for this process functioning as part of a larger complex. This protein complex interaction ensures the correct division of cells and proper inheritance of cellular components.
Pathways
CEP55 plays an integral role in the ESCRT (Endosomal Sorting Complex Required for Transport) machinery which is important for membrane remodeling. It also integrates into the cell cycle pathway influencing the transition from mitosis to cytokinesis. CEP55 interacts with proteins like ALIX and TSG101 within these pathways facilitating appropriate signaling and structural assembly to ensure successful cell division.
CEP55 is associated with cancer development and progression due to its role in cell division. Overexpression or misregulation of CEP55 can lead to uncontrolled cell proliferation often seen in various malignancies. CEP55 is connected to proteins such as PLK1 which also partakes in regulating cell cycle checkpoints therefore forming a potential target for cancer therapeutics. Another condition tied to CEP55 is microcephaly a genetic disorder caused by impaired cell division during neuronal development.