Abcam, ab163508, Recombinant Human Pellino 2 protein

Size: 10µg
Recombinant Human Pellino 2 protein is a Human Full Length protein, in the 1 to 420 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9HAT8,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pellino 2 also known as PELI2 is an E3 ubiquitin ligase. It is about 45 kDa in mass and exists in the cytoplasm. This protein plays an important role in the regulation of the innate immune response. It is highly expressed in immune cells like monocytes and macrophages as well as in tissues such as the spleen and lymph nodes. As an adaptor molecule Pellino 2 modifies proteins by attaching ubiquitin which tags them for degradation or alters their activity.
Biological function summary
Pellino 2 engages in downstream signaling of immune receptors. It has a critical role in the activation of transcription factors contributing to the production of pro-inflammatory cytokines. Acting in a complex with other components like TRAF proteins it regulates the nuclear factor kappa B (NF-kB) signaling pathway. Through this regulation Pellino 2 influences inflammatory responses and aids in controlling the duration and intensity of inflammation.
Pathways
Pellino 2 integrates into the Toll-like receptor (TLR) and interleukin-1 (IL-1) signaling pathways. These pathways are fundamental for initiating the innate immune response upon detecting pathogens. Pellino 2 interacts with proteins like IRAK4 and MyD88 in these pathways facilitating the activation and amplification of signal cascades that lead to NF-kB and mitogen-activated protein kinase (MAPK) activation which further influence gene expression and immune responses.
Pellino 2 links with inflammatory conditions such as rheumatoid arthritis and cardiovascular disease. Abnormal regulation or expression of Pellino 2 may enhance inflammatory signaling contributing to the pathogenesis of these disorders. The protein's interaction with NF-kB an important player in many inflammatory diseases makes it an important factor in understanding and potentially modulating these pathological processes.