Abcam, ab164147, Recombinant Human THSD4 protein

Size: 10µg
Recombinant Human THSD4 protein is a Human Full Length protein, in the 1 to 490 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q6ZMP0,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THSD4 also known as Thrombospondin Type 1 Domain-Containing Protein 4 or ADAMTSL6 is a protein involved in extracellular matrix interactions. It has a molecular mass of approximately 120 kDa. The protein is expressed in various tissues including connective tissues and the heart. THSD4 plays a role in forming and maintaining the structure of the extracellular matrix influencing tissue integrity and function.
Biological function summary
This protein interacts with components of the extracellular matrix contributing to its stability and elasticity. It participates in the formation of a larger protein complex cooperating with fibrillin and fibulin family proteins. By integrating into these complexes THSD4 contributes to the structural network that supports cellular functions and tissue resilience under mechanical stress.
Pathways
THSD4 influences extracellular matrix organization pathways and connective tissue development. It interacts with other ECM proteins such as fibrillin-1 and fibulin-2 contributing to the structural integrity of tissues. Through these interactions THSD4 ensures proper assembly and function within tissues impacting cell signaling and mechanical properties of the matrix.
THSD4 relates to connective tissue diseases and cardiovascular disorders. Mutations or dysfunctions in this protein can lead to conditions like Marfan syndrome and thoracic aortic aneurysms which compromise tissue elasticity and strength. The protein shares functional connections with fibrillin-1 and elastin both of which are significant in the maintenance of vascular and connective tissue integrity.