Abcam, ab164191, Recombinant Human SEMA6D protein

Size: 10µg
Recombinant Human SEMA6D protein is a Human Fragment protein, in the 852 to 940 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8NFY4,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein SEMA6D also known as Semaphorin-6D is a member of the semaphorin family characterized by its role in cell signaling. SEMA6D has a molecular mass of approximately 119 kDa. It is expressed in various tissues including the heart nervous system and certain immune cells. Mechanically SEMA6D functions through its interactions with plexin receptors particularly Plexin-A1 facilitating signal transduction that regulates cellular movement and organization.
Biological function summary
Semaphorin-6D contributes to multiple processes like axon guidance cardiac morphogenesis and immune function. It does not exist as part of a larger complex but acts through receptor interactions that lead to activation of downstream signaling pathways. Semaphorin-6D plays an influential role in guiding neuronal pathfinding during development ensuring proper formation of neural networks and also affects the organization and function of cardiac tissues.
Pathways
Semaphorin-6D modulates the activity in signaling systems like the RhoA/ROCK pathway and the MAPK pathway. These pathways are important for cytoskeletal dynamics and cell migration. It interacts with Plexin-A1 which assists in signal transmission leading to alterations in cell shape and motility. The involvement of SEMA6D in these pathways indicates its significance in cellular rearrangements and tissue architecture.
Semaphorin-6D has associations with cardiac malformations and certain neurological disorders. Abnormal SEMA6D signaling can contribute to congenital heart defects where improper cardiac development is linked to its interaction with Plexin-A1 and downstream effectors. Additionally its dysregulation has been observed in neurodegenerative diseases emphasizing its involvement in maintaining neural structure and function. These connections highlight Semaphorin-6D's importance in both developmental and pathological contexts.