Abcam, ab164865, Recombinant Human SLFN11 protein

Size: 10µg
Recombinant Human SLFN11 protein is a Human Full Length protein, in the 1 to 901 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q7Z7L1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLFN11 also known as Schlafen family member 11 is an important protein involved in the regulation of cellular response to DNA damage. With a molecular mass of approximately 104 kDa SLFN11 is extensively expressed in tumor cells and certain normal tissues particularly in the spleen thymus and testis. This protein contributes to the modulation of interferon-mediated immune responses and impacts translational control by tRNA activation playing a role in ribosomal assembly and function.
Biological function summary
SLFN11 functions to enhance the sensitivity of cells to DNA-damaging agents including chemotherapeutic drugs. It is important for impairing replication fork stability by inhibiting the expression of trans-translation machinery. SLFN11 serves as an important determinant within the DNA damage response (DDR) network and is known to interact with other DDR proteins emphasizing its impact on genome integrity and cellular survival under stress conditions.
Pathways
SLFN11 plays a notable role within the pathways associated with the DNA damage response and cell cycle regulation. The protein interacts notably with the ATR signaling pathway which is essential for sensing DNA damage. Additionally SLFN11 forms part of a complex interaction with other DNA repair proteins such as BRCA1 influencing the homologous recombination repair pathway contributing to the cellular determination of treatment response.
SLFN11 has significant implications in cancer particularly in the context of treatment response to chemotherapy. Cancers with high SLFN11 expression often exhibit increased sensitivity to cisplatin and other DNA-damaging agents pointing to its potential role as a biomarker for therapeutic efficacy. Moreover the protein is implicated in neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) where its regulation could contribute to the pathophysiology. Its relationship with proteins such as p53 further highlights SLFN11's involvement in cancer and neuroprotection pathways.