Abcam, ab165001, Recombinant Human STF2D1 protein

Size: 10µg
Recombinant Human STF2D1 protein is a Human Full Length protein, in the 1 to 159 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8WV19,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STF2D1 also known as Spindle and Kinetochore Associated Complex Subunit 2 is a protein with a molecular weight of around 48 kDa. It is expressed in various tissues notably in highly proliferative cells. STF2D1 interacts with microtubules during cell division playing a mechanical role in the spindle assembly and positioning. It ensures proper chromosome segregation and mitotic progression essential for maintaining genomic stability.
Biological function summary
STF2D1 is involved in the regulation of the mitotic spindle apparatus. It is an integral part of the spindle-kinetochore complex where it contributes to the attachment of microtubules to kinetochores. This interaction is critical for chromosome alignment and segregation during mitosis influencing the cell cycle's fidelity. Alterations in STF2D1 can affect cellular proliferation and may have consequences on tissue homeostasis.
Pathways
STF2D1 is an important component in cell cycle regulation particularly during the mitotic checkpoint. It interacts with key cell cycle proteins like Aurora B kinase and BubR1 influencing the spindle checkpoint pathway. These interactions help monitor and correct improper kinetochore-microtubule attachments to prevent aneuploidy. STF2D1's role in these pathways emphasizes its importance in ensuring accurate cell division and genetic stability.
Disruptions in STF2D1 function are linked to cancer and congenital aneuploidy disorders. In certain cancers STF2D1 may become overexpressed contributing to unchecked cell division and tumor progression. It is related to proteins like p53 and BCL2 through these malignancy pathways which affect apoptosis and cell cycle arrest. Understanding STF2D1's role in these diseases can inform therapeutic approaches that target cell division abnormalities.