Abcam, ab165129, Recombinant Human GPCR MRGX2 protein

Size: 2µg
Recombinant Human GPCR MRGX2 protein is a Human Full Length protein, in the 1 to 330 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q96LB1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
G protein-coupled receptor MRGX2 also known as MAS-related GPR member X2 is a protein involved in signaling processes. This receptor has a mass of around 37 kDa and is part of the large GPCR family known for transmitting signals from outside to inside the cell. MRGX2 expresses primarily in sensory neurons of the dorsal root ganglia and skin mast cells where it plays a significant role in sensory perception and inflammatory responses.
Biological function summary
MRGX2 functions by interacting with a variety of neuropeptides and small molecules acting as a mediator of itch and pain. This receptor is involved in mast cell degranulation making it a part of the immune response complex. It helps regulate the release of histamines and other inflammatory mediators contributing to the body's defense mechanisms against various stimuli.
Pathways
MRGX2 is an essential component in the G protein-coupled receptor signaling pathway particularly influencing the PI3K/AKT signaling cascade. This pathway includes interactions with related proteins like phosphoinositide-dependent kinase-1 and AKT1 which are important for cell survival and growth. MRGX2's involvement in these pathways underlines its importance in mediating responses to allergic and inflammatory triggers.
MRGX2 has been implicated in chronic pruritus and atopic dermatitis conditions marked by persistent itch and inflammation. Its interaction with other receptors such as the histamine H1 receptor demonstrates its role in these dermatological issues. Understanding MRGX2's role and related pathways offers potential therapeutic targets for managing these skin disorders effectively.