Abcam, ab165297, Recombinant Human Olfactory receptor 10X1 protein

Size: 10µg
Recombinant Human Olfactory receptor 10X1 protein is a Human Full Length protein, in the 1 to 309 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8NGY0,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Olfactory receptor 10X1 also known as OR10X1 is a protein involved in the detection of odorants. This receptor is part of the G-protein coupled receptor (GPCR) family and has a mass of around 34 kDa. OR10X1 is expressed predominantly in the olfactory epithelium located in the nasal cavity. It interacts with odor molecules initiating a cascade of intracellular signals leading to the perception of smell in the brain.
Biological function summary
The receptor facilitates the first step of olfactory signal transduction by binding specific odorant molecules. Transduction involves coupling with G proteins which then activate adenylate cyclase to convert ATP to cAMP. This increase in cAMP opens cyclic nucleotide-gated ion channels resulting in changes in neuronal excitability that transmit signals to the brain. OR10X1 functions within a large family of olfactory receptors and does not exist alone; it is part of a vast network that distinguishes a wide array of smells.
Pathways
The involvement of OR10X1 in the signaling of olfactory pathways begins with the detection of odorant molecules. The receptor plays a role in the olfactory signaling pathway interacting closely with G proteins such as G_olf which is specific to the olfactory system. Another critical pathway is the cAMP-dependent signaling where OR10X1 regulates neuronal response to environmental odor cues by modulating cAMP levels. These interactions allow for precise olfactory discrimination essential for survival.
Alterations in OR10X1 function or expression can relate to conditions like anosmia which is the loss of smell. Disruption in OR10X1 activity could also play a role in olfactory dysfunctions that appear in neurological diseases such as Alzheimer's disease. These diseases involve complex interactions with proteins like amyloid-beta or tau highlighting the critical role of olfactory receptors like OR10X1 in normal and diseased states.