Abcam, ab165797, Recombinant Human Olig3 protein

Size: 10µg
Recombinant Human Olig3 protein is a Human Full Length protein, in the 1 to 272 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q7RTU3,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Olig3 also known as Oligodendrocyte transcription factor 3 acts as a basic helix-loop-helix (bHLH) transcription factor. It has a mass of about 31 kDa and plays an important role in regulating gene expression. You typically find it expressed in developing neural tissues especially in the central nervous system. In humans it is located on chromosome 6 where its precise control is necessary for proper neural development.
Biological function summary
Olig3 regulates the development of specific neurons in the central nervous system. It does not operate alone but often forms heterodimers with other bHLH transcription factors to exert its influence. Researchers have shown its involvement in neurogenesis particularly in defining neuronal cell fate. By activating or repressing specific genes it fine-tunes the development of neural progenitor cells into specialized neuron types.
Pathways
Olig3 integrates into the Notch and Sonic Hedgehog signaling pathways. It influences neuronal differentiation through these pathways often interacting with proteins like Hes1 which is part of the Notch pathway. Sonic Hedgehog also plays a role in guiding the spatial expression patterns where Olig3 is active ensuring a balanced developmental process. These pathways are essential for the correct propagation of signals that dictate the specification of neuronal cell lineages.
Olig3 has been implicated in medulloblastoma and certain developmental disorders. Dysregulation of Olig3 expression and function can contribute to tumor formation in the cerebellum often in conjunction with associated proteins such as Gli1 from the Sonic Hedgehog pathway. Abnormalities in Olig3 expression may also link to developmental neuroissues due to its foundational role in neuron formation and differentiation.