Abcam, ab165873, Recombinant Human OSTA protein

Size: 10µg
Recombinant Human OSTA protein is a Human Full Length protein, in the 1 to 340 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q86UW1,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein "OSTA" plays a significant role in cellular processes through its structural and functional characteristics. Its alternate names include "Osteocalcin Transporter Associated" and "OST-alpha." The molecular mass of OSTA is approximately 40 kDa. The protein is mainly expressed in the intestinal epithelium liver and kidneys suggesting it has a role in nutrient absorption and detoxification. It operates as a transporter facilitating the movement of various molecules across cell membranes.
Biological function summary
OSTA contributes to maintaining homeostasis by transporting bile acids and sterols. It functions within a larger complex known as the heteromeric organic solute transporter comprising OST-alpha and OST-beta subunits. This complex plays a critical role in enterohepatic circulation which manages the recapture and redistribution of bile acids from the intestine to the liver thereby maintaining lipid metabolism balance.
Pathways
OSTA impacts the enterohepatic circulation pathway and interacts with proteins such as NR1H4 (or FXR) to regulate bile acid levels. In the lipid metabolism pathway its ability to facilitate bile acid transport connects it to cholesterol homeostasis influencing absorption and excretion. Its operation alongside proteins like OST-beta further accentuates how it modulates these pathways sustaining systemic cholesterol levels.
Alterations in OSTA expression or function associate with conditions like cholestasis and metabolic syndrome. Cholestasis involves impaired bile flow where OSTA malfunction can exacerbate cholesterol buildup. In metabolic syndrome it influences lipid distribution in the body. Interactions with proteins like FXR highlight its role in these conditions linking OSTA malfunctions with disrupted metabolic function and disease progression.