Abcam, ab16718, Anti-Kv1.4/RK3 antibody

Size: 100µg
Rabbit Polyclonal Kv1.4/RK3 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Precipitation Ammonium Sulphate, Storage buffer-Preservative: 0.08% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kv1.4 also known as RK3 functions as a voltage-gated potassium channel. It allows for potassium ions to move across the cell membrane in response to changes in membrane potential. This channel has a molecular mass around 75 kDa. Kv1.4 is mainly expressed in cardiac and neuronal tissues where it plays an important role in action potential repolarization. Its expression ensures proper electrical signaling in these tissues.
Biological function summary
The Kv1.4 channel contributes to the regulation of action potentials in both the heart and nervous system. It is part of a larger complex of potassium channels that work together to fine-tune neuronal excitability and muscle contraction. The function of Kv1.4 is essential for maintaining the balance of excitation and inhibition in cells impacting how electrical signals are transmitted.
Pathways
Kv1.4 has a significant role in the cardiac action potential pathway and the neural signaling pathway. In the cardiac pathway it interacts with other potassium channels like Kv1.2 and Kv1.1 to ensure the timely repolarization of the cardiac action potential. In neural tissues Kv1.4 affects neurotransmitter release and neuronal firing rates interacting with proteins such as synaptotagmin in the synaptic vesicle fusion process.
Kv1.4 mutations and dysregulation are connected to cardiac arrhythmias and epilepsy. Altered Kv1.4 function can disrupt the cardiac rhythm leading to arrhythmogenic conditions. In epilepsy abnormal Kv1.4 activity may lead to imbalanced neuronal excitability which can contribute to seizure disorders. Kv1.4 interacts with other proteins like Nav1.1 in these disease states to exacerbate or mitigate symptoms.