Abcam, ab167197, Anti-MIIP antibody

Size: 50µg
Mouse Polyclonal MIIP antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MIIP.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human MIIP.Q5JXC2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MIIP also known as Migration and Invasion Inhibitory Protein is a protein with a mass of approximately 47 kDa. It acts mechanically as an important regulator of cellular movement and invasion processes. MIIP expression occurs in various tissues including the brain and reproductive organs. Scientists recognize MIIP for its role in modulating cytoskeletal dynamics and protein interactions that affect cell motility.
Biological function summary
MIIP plays a significant role in inhibiting cell migration and invasion contributing to its function as a tumor suppressor. It interacts with important components of the cytoskeletal network and may work together with other proteins to form complexes that stabilize actin filaments. Through these interactions MIIP helps control cellular structure integrity and movement impacting the invasive potential of cells.
Pathways
MIIP impacts several key signaling pathways. It integrates into the PI3K/AKT signaling pathway which influences cell survival and proliferation. This protein also interacts within the Wnt/β-catenin pathway known for its role in cell growth and development. MIIP's association with these pathways links it to interactions with proteins like AKT and β-catenin creating a regulatory network that balances normal and pathological cell behavior.
MIIP is associated with cancer and its progression. Studies have shown that reduced MIIP expression correlates with increased tumor invasiveness and metastasis particularly in gliomas and breast cancer. In these contexts MIIP interacts with proteins such as matrix metalloproteinases (MMPs) which aid in tissue invasion. By inhibiting these interactions MIIP exerts a protective effect against tumor progression highlighting its potential as a therapeutic target.