Abcam, ab167224, Anti-EDA2R/XEDAR antibody

Size: 50µg
Mouse Polyclonal EDA2R/XEDAR antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human EDA2R.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human EDA2R.Q9HAV5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The EDA2R also known as XEDAR (X-linked Ectodermal Dysplasia Receptor) is a member of the tumor necrosis factor receptor superfamily. This protein has a mass of approximately 42 kDa. EDA2R is expressed widely in various tissues including the skin hair follicles and glands. Its mechanical role involves binding to specific members of the ectodysplasin family mediating downstream signaling.
Biological function summary
The EDA2R protein engages in ectodermal development processes. It is involved in the formation of skin hair and sweat glands. EDA2R functions by activating signaling pathways that regulate cell development and differentiation. Though primarily a solo actor it interacts with other molecules to carry out its biological actions effectively.
Pathways
EDA2R is actively involved in the NF-kappa B signaling pathway and may intersect with the Wnt signaling pathway. These pathways influence various cellular responses like inflammation and cell growth. EDA2R shares functional pathways with proteins such as EDAR and EDARADD which facilitate the signals through similar or connected mechanisms in the organization of ectodermal structures.
EDA2R has been specifically associated with ectodermal dysplasia a group of disorders affecting skin hair and glands. Mutations or malfunctions in EDA2R can lead to abnormal developments in these tissues. EDA2R also shows relevance in certain cancers where its expression level can impact tumor growth and survival. In both contexts EDAR is a connected protein that often partners with EDA2R to influence disease progression.