Abcam, ab167477, Anti-CEACAM16 antibody [SU-9D5]

Size: 100µg
Mouse Monoclonal CEACAM16 antibody. Carrier free. Suitable for Flow Cyt, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SU-9D5,
Isotype:IgG2b,
Carrier free:Yes,
Reacts with:Mouse, Human,
Applications:Flow Cyt, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab167477 was purified by protein G affinity chromatography from cell culture supernatants and verified by SDS-PAGE., Storage buffer-pH: 7.2Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEACAM16 also known as Carcinoembryonic Antigen-Related Cell Adhesion Molecule 16 has a significant role in the auditory system. The protein has a mass approximately of 48 kDa and it is expressed mainly in the inner ear specifically within the cochlear and vestibular systems. CEACAM16 localizes at the tectorial membrane and is part of the structure involved in sensory hair cell function. Its expression is essential for the proper organization and mechanics of the tectorial membrane which contributes to sound perception.
Biological function summary
CEACAM16 interacts with other proteins to maintain auditory function. It is part of a complex that includes tectorial membrane proteins like TECTA (alpha-tectorin) and OTOA (otoancorin). CEACAM16 supports the structural integrity of the tectorial membrane facilitating the transmission of sound-induced vibrations to sensory hair cells. This interaction is critical for the proper mechanotransduction processes essential for hearing.
Pathways
CEACAM16 plays a role in hearing-related molecular pathways. It interacts within the mechanotransduction pathway which is important for converting mechanical sound stimuli into electrical signals in the ear. CEACAM16 also relates to pathways concerning extracellular matrix organization as it helps to maintain the tectorial membrane structure. Proteins such as collagen and other tectorial membrane components like TECTA and TECTB (beta-tectorin) are closely related within these pathways directly influencing auditory transduction efficiency.
CEACAM16 mutations or dysfunctions can lead to non-syndromic hearing loss. Mutations affecting CEACAM16 have been linked with autosomal dominant progressive hearing loss known as DFNA4B. This type of hearing impairment often involves mutations impacting the mechanotransduction pathway. Furthermore CEACAM16 has associations with proteins involved in genetic forms of deafness such as TECTA further illustrating its importance in maintaining auditory health.