Abcam, ab167645, Anti-TCR alpha antibody

Size: 50µg
Mouse Polyclonal TRAC antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TRAC.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TRAC.P01848

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TCR alpha also known as T cell receptor alpha or alfa TCR is an essential component of the T cell receptor (TCR) complex. It is a transmembrane protein with a typical mass of approximately 50-55 kDa. The TCR alpha chain together with the TCR beta chain forms the heterodimer that is critical for antigen recognition. This receptor complex is expressed on the surface of T cells specifically on mature T cells that have undergone successful TCR rearrangement. The interaction of TCR alpha with major histocompatibility complex (MHC) molecules loaded with antigen peptides leads to T cell activation.
Biological function summary
TCR alpha plays a central role in immune response by recognizing antigens presented by MHC. TCR alpha chain is part of a larger T cell receptor complex which includes the CD3 signaling molecules. The binding of antigens triggers a signal transduction cascade through CD3 components leading to T cell activation proliferation and differentiation into effector T cells. These effector cells then participate in immune defenses against pathogens and are important for immune surveillance. TCR alpha's interaction with the environment and antigens initiates immune synapse formation leading to proper signal transmission.
Pathways
TCR alpha is an important participant in the T cell receptor signaling pathway. This pathway plays an important role in T cell activation and function linking innate and adaptive immunity. TCR alpha interacts with several signaling proteins such as Lck and ZAP-70 which propagate the signal downstream to various transcription factors that modulate gene expression. This cascade affects cellular processes including cytokine production and survival further connecting the TCR signaling pathway to other pathways like the MAP kinase signaling pathway.
TCR alpha has been associated with autoimmune diseases and immunodeficiencies. Alterations in TCR alpha chain can lead to conditions such as systemic lupus erythematosus where an improper response of T cells to self-antigens occurs. Moreover mutations or malfunctions in TCR alpha expression can result in severe combined immunodeficiency (SCID) where patients have a severely compromised immune system. Other proteins such as CD3 and MHC are involved in both autoimmune diseases and immunodeficiencies showing the interconnected nature of immune components and the importance of TCR alpha in maintaining immune homeostasis.